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Patients with multiple myeloma, diabetes, and high uric acid levels are particularly vulnerable to complications related to hydration status when undergoing imaging studies with contrast administration.

Multiple myeloma can lead to renal impairment because of the presence of abnormal proteins that can clog the renal tubules, increasing the risk of acute kidney injury when contrast is administered. Diabetes, especially in those with nephropathy, can further complicate kidney function, making hydration status critical to ensure that the kidneys can handle the contrast material without sustaining damage. High uric acid levels can also indicate potential kidney issues and raise the risk of gout or kidney stones, which can be exacerbated by the administration of contrast agents.

These patient groups thus require careful screening for hydration to ensure adequate renal function and minimize the risk of adverse reactions to contrast media, particularly nephrotoxicity. Ensuring these patients are well-hydrated can help to mitigate these risks and improve their overall safety during imaging procedures.